Clinical Publications
To access the articles, please click on the link below to register.

We ask that you limit your downloads of these reprints to one of each as well as save them to your desktop for future reference, as there are a limited number of downloads available.

• Nallamothu BK, Bates ER, et. al. "Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States." Circulation. 2005;111:761-767. Register for free access to the full article.



• Mehta RH, Alexander JH, et. al. "Relationship of Incorrect Dosing of Fibrinolytic Therapy & Clinical Outcomes." JAMA. 2005;293:1746-1750. Register for free access to the full article.

Professional Resources

• Download the TNKase Palm Pilot Tool
  The TNKase Palm Pilot Tool provides quick reference materials on your handheld device.



• Clinical Brochure



• Dosing Sheet



• Rapid ECG Interpretation Insert

Additional Materials
The additional materials listed above are available as downloadable PDF files for your convenience. To open these documents, please download the latest version of Adobe Acrobat Reader, a free download.

Indication: For use in mortality reduction associated with acute myocardial infarction (AMI). Treatment should be initiated as soon as possible after the onset of AMI symptoms.

Safety Information: TNKase therapy is contraindicated in the following conditions due to an increased risk of bleeding: active internal bleeding, history of cerebrovascular accident, intracranial or intraspinal surgery or trauma within 2 months, intracranial neoplasm, arteriovenous malformation, or aneurysm, known bleeding diathesis, and severe uncontrolled hypertension.

All thrombolytic agents increase the risk of bleeding, including intracranial bleeding, and should be used only in eligible patients. In addition, thrombolytic therapy increases the risk of stroke, including hemorrhagic stroke, particularly in elderly patients. In patients with large ST segment elevation myocardial infarction, physicians should choose either thrombolysis or percutaneous coronary intervention (PCI) as the primary treatment strategy for reperfusion. Rescue PCI or subsequent elective PCI may be performed after administration of thrombolytic therapies if medically appropriate.